Department of Chemistry, Jadavpur University, Kolkata 700032, West Bengal, India.
J Org Chem. 2010 Mar 5;75(5):1674-83. doi: 10.1021/jo902661y.
A simple, convenient, and multicomponent coupling strategy for the synthesis of highly functionalized pyrroles catalyzed by iron(III) salts has been developed. This strategy demonstrated four-component coupling reactions of 1,3-dicarbonyl compounds, amines, aromatic aldehydes, and nitroalkanes without an inert atmosphere. This methodology provides an alternative approach for easy access of highly substituted pyrroles in moderate to very good yields using four simple and readily available building blocks via one-pot tandem reaction. Notably, this method is very cheap, straightforward, and environmentally friendly compared to the existing methods.
一种简单、方便、多组分的铁(III)盐催化合成高度官能化吡咯的方法已经被开发出来。该策略在无需惰性气氛的情况下，展示了 1,3-二羰基化合物、胺、芳醛和硝基烷烃的四组分偶联反应。该方法提供了一种替代方法，可通过一锅串联反应，以中等至非常好的收率，使用四个简单易得的构建块，轻松获得高取代吡咯。值得注意的是，与现有方法相比，该方法非常廉价、直接且环保。
