Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 25, 79104 Freiburg, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar;383(3):227-35. doi: 10.1007/s00210-010-0579-5. Epub 2010 Nov 12.
Photorhabdus luminescens produces several types of protein toxins, which are essential for participation in a trilateral symbiosis with nematodes and insects. The nematodes, carrying the bacteria, invade insect larvae and release the bacteria, which kill the insects with their toxins. Recently, the molecular mechanisms of the toxin complexes PTC3 and PTC5 have been elucidated. The biologically active components of the toxin complexes are ADP-ribosyltransferases, which modify actin and Rho GTPases, respectively. The actions of the toxins are described and compared with other bacterial protein toxins acting on the cytoskeleton.
发光杆菌产生多种类型的蛋白毒素，这些毒素对于与线虫和昆虫的三方共生关系至关重要。携带细菌的线虫会侵入昆虫幼虫并释放细菌，细菌利用其毒素杀死昆虫。最近，毒素复合物 PTC3 和 PTC5 的分子机制已经阐明。毒素复合物的生物活性成分是 ADP-ribosyltransferases，分别修饰肌动蛋白和 Rho GTPases。本文描述了这些毒素的作用，并与其他作用于细胞骨架的细菌蛋白毒素进行了比较。
