Aktories Klaus, Schmidt Gudula, Lang Alexander E
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany,
Curr Top Microbiol Immunol. 2015;384:53-67. doi: 10.1007/82_2014_382.
The ADP-ribosyltransferases TccC3 and TccC5 are the biologically active TcC components of the tripartite Photorhabdus luminescens Tc toxin, which consist of TcA, TcB, and TcC components. TcA is the binding and membrane translocation component. TcB is a functional linker between TcC and TcA and also involved in the translocation of the toxin. While TccC3 ADP-ribosylates actin at threonine 148, TccC5 modifies Rho proteins at glutamine 61/63. Both modifications result in major alteration of the actin cytoskeleton. Here we discuss structure and function of the Tc toxin and compare its ADP-ribosyltransferase activities with other types of actin and Rho modifying toxins.
ADP核糖基转移酶TccC3和TccC5是发光光杆状菌三方Tc毒素具有生物活性的TcC组分，该毒素由TcA、TcB和TcC组分组成。TcA是结合和膜转运组分。TcB是TcC和TcA之间的功能性连接物，也参与毒素的转运。TccC3在苏氨酸148处对肌动蛋白进行ADP核糖基化，而TccC5在谷氨酰胺61/63处修饰Rho蛋白。这两种修饰都会导致肌动蛋白细胞骨架发生重大改变。在此，我们讨论Tc毒素的结构和功能，并将其ADP核糖基转移酶活性与其他类型的肌动蛋白和Rho修饰毒素进行比较。
