Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135710, South Korea.
World J Gastroenterol. 2010 Nov 14;16(42):5353-8. doi: 10.3748/wjg.v16.i42.5353.
To identify preoperative predictive factors associated with malignancy of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas.
Between April 1995 and April 2010, 129 patients underwent surgical resection for IPMNs at our institute and had confirmed pathologic diagnoses. The medical records were retrospectively reviewed and immunohistochemical staining for mucin (MUC) in pancreatic tissues was performed.
Univariate analysis showed that the following five variables were closely associated with malignant IPMNs preoperatively: absence of extrapancreatic malignancy; symptoms; tumor size > 4 cm; main pancreatic duct (MPD) size > 7 mm; and lymph node enlargement on preoperative computed tomography (CT). Multivariate analysis revealed that the following two factors were significantly associated with malignant IPMNs preoperatively: MPD size > 7 mm [odds ratio (OR) = 2.50]; and lymph node enlargement on preoperative CT (OR = 3.57). No significant differences in the expression of MUC1, MUC2 and MUC5AC were observed between benign and malignant IPMNs.
MPD size > 7 mm and preoperative lymph node enlargement on CT are useful predictive factors associated with malignancy of IPMNs.
确定与胰腺内导管乳头状黏液性肿瘤（IPMNs）恶性相关的术前预测因素。
1995 年 4 月至 2010 年 4 月，我院对 129 例 IPMN 患者进行了手术切除，并获得了明确的病理诊断。对这些患者的病历进行了回顾性分析，并对胰腺组织进行了黏液（MUC）免疫组织化学染色。
单因素分析显示，以下五个变量与术前恶性 IPMNs 密切相关：无胰腺外恶性肿瘤；症状；肿瘤大小>4cm；主胰管（MPD）大小>7mm；术前 CT 显示淋巴结肿大。多因素分析显示，MPD 大小>7mm（比值比[OR] = 2.50）和术前 CT 显示淋巴结肿大（OR = 3.57）是与恶性 IPMNs 显著相关的两个因素。在良性和恶性 IPMNs 之间，MUC1、MUC2 和 MUC5AC 的表达没有显著差异。
MPD 大小>7mm 和术前 CT 显示淋巴结肿大是与 IPMNs 恶性相关的有用预测因素。
