Sorci Guglielmo, Riuzzi Francesca, Arcuri Cataldo, Bianchi Roberta, Brozzi Flora, Tubaro Claudia, Giambanco Ileana, Donato Rosario
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia.
Ital J Anat Embryol. 2010;115(1-2):147-51.
The Ca(2+)-binding protein of the EF-hand type, S100B, is an intracellular regulator and an extracellular signal. Within cells S100B interacts with several proteins thereby regulating energy metabolism, Ca2+ homeostasis, protein phosphorylation and degradation, and cell locomotion, proliferation and differentiation. Once secreted/released, S100B exerts autocrine and paracrine effects on responsive cells by engaging the receptor for advanced glycation end products. However, recent evidence suggests that S100B might also activate basic fibroblast growth factor receptor 1 via prior binding to basic fibroblast growth factor.
EF 手型钙结合蛋白 S100B 是一种细胞内调节剂和细胞外信号。在细胞内，S100B 与多种蛋白质相互作用，从而调节能量代谢、钙稳态、蛋白质磷酸化和降解以及细胞运动、增殖和分化。一旦分泌/释放，S100B 通过与晚期糖基化终产物受体结合，对反应性细胞发挥自分泌和旁分泌作用。然而，最近的证据表明，S100B 也可能通过预先与碱性成纤维细胞生长因子结合来激活碱性成纤维细胞生长因子受体 1。
