Wu J T, Liu Z H
Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester 01655.
J Reprod Fertil. 1990 Jan;88(1):93-8. doi: 10.1530/jrf.0.0880093.
When mouse morulae, early blastocysts and implanting blastocysts were cultured with tritiated pregnenolone, tritiated progesterone and its metabolites, 5 alpha-pregnan-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one, were isolated from the medium. It appears that mouse embryos can make progesterone from pregnenolone and the progesterone is quickly metabolized into various metabolites. These abilities increase with development. It is suggested that the mouse embryo can make progesterone and may regulate its own progesterone level for optimal development.
当将小鼠桑葚胚、早期囊胚和着床期囊胚与氚标记的孕烯醇酮、氚标记的孕酮及其代谢产物5α-孕烷-3,20-二酮和3α-羟基-5α-孕烷-20-酮一起培养时，从培养基中分离出了这些物质。似乎小鼠胚胎能够将孕烯醇酮转化为孕酮，并且孕酮会迅速代谢为各种代谢产物。这些能力随着发育而增强。提示小鼠胚胎能够合成孕酮，并可能调节自身的孕酮水平以实现最佳发育。
