Institute for Infectious and Tropical Diseases, Clinical Center of Serbia, Bulevar oslobodenja 16, 11000 Belgrade, Serbia.
Parasite. 2010 Sep;17(3):199-204. doi: 10.1051/parasite/2010173199.
A retrospective study of the course and outcome of trichinellosis in a series of 50 patients hospitalized at the Institute for Infectious and Tropical Diseases in Belgrade between 2001 and 2008 was performed. Clinical diagnosis of trichinellosis was based upon the patients' clinical history, symptoms and signs, and eosinophilia. The occurrence of cases showed a strong seasonality (P < 0.0001). The incubation period ranged between one and 33 days. The mean time between onset of symptoms and admission was nine days. Family outbreaks were the most frequent. Smoked pork products were the dominant source of infection (76%). Fever was the most frequent clinical manifestation (90%), followed by myalgia (80%) and periorbital edema (76%). 43 patients were examined serologically and 72% of them had anti-Trichinella antibodies. Eosinophilia and elevated levels of serum CK and LDH were detected in 94, 50 and 56% of the patients, respectively. All patients responded favorably to treatment with mebendazole or albendazole, but eight developed transient complications. Trichinellosis remains a major public health issue in Serbia.
对 2001 年至 2008 年期间在贝尔格莱德传染病和热带病研究所住院的 50 例旋毛虫病患者的病程和转归进行了回顾性研究。旋毛虫病的临床诊断基于患者的临床病史、症状和体征以及嗜酸性粒细胞增多症。病例发生具有很强的季节性（P<0.0001）。潜伏期在 1 至 33 天之间。症状出现到入院的平均时间为九天。家庭爆发是最常见的。熏猪肉制品是主要的感染源（76%）。发热是最常见的临床表现（90%），其次是肌痛（80%）和眶周水肿（76%）。43 例患者进行了血清学检查，其中 72%的患者有抗旋毛虫抗体。嗜酸性粒细胞增多症和血清 CK 和 LDH 水平升高分别在 94%、50%和 56%的患者中检测到。所有患者对甲苯咪唑或阿苯达唑治疗反应良好，但有 8 例出现短暂并发症。旋毛虫病仍然是塞尔维亚的一个主要公共卫生问题。
