Regulation of genes involved in sugar uptake, glycolysis and lactate production in Corynebacterium glutamicum.

Corynebacterium glutamicum is a nonpathogenic, GC-rich, Gram-positive bacterium with a long history in the industrial production of amino acids. Recently, the species has become of increasing interest as a model bacterium for closely related, medically important pathogenic species such as Corynebacterium diphtheriae and Mycobacterium tuberculosis. In this article, recent advances in understanding of the C. glutamicum regulatory network of genes involved in carbohydrate metabolism are reviewed with regards to sugar uptake, glycolysis and lactate production.