Antunes Carla Valéria de Alvarenga, Hallack Neto Abrahão Elias, Nascimento Cristiano Rodrigo de Alvarenga, Chebli Liliana Andrade, Moutinho Ivana Lúcia Damásio, Pinheiro Bruno do Valle, Reboredo Maycon Moura, Malaguti Carla, Castro Antonio Carlos Santana, Chebli Júlio Maria Fonseca
Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Diseases Center, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine, Avenida Eugênio do Nascimento s/n°, Dom Bosco, 36038-330 Juiz de Fora, MG, Brazil.
Biomed Res Int. 2015;2015:728925. doi: 10.1155/2015/728925. Epub 2015 Feb 1.
Anemia is common in inflammatory bowel disease (IBD). However, epidemiological studies of nonwestern IBD populations are limited and may be confounded by demographic, socioeconomic, and disease-related influences. This study evaluated the prevalence, risk factors, and etiology of anemia in Brazilian outpatients with IBD.
In this cross-sectional study, 100 Crohn's disease (CD) patients and 100 ulcerative colitis (UC) subjects were assessed. Anemia workup included complete blood count, ferritin, transferrin saturation, serum levels of folic acid and vitamin B12, and C-reactive protein (CRP) concentration.
The overall prevalence of anemia in IBD was 21%. There was no significant difference in the prevalence of anemia between CD subjects (24%) and UC (18%). Moderate disease activity (OR: 3.48, 95% CI, 1.95-9.64, P = 0.002) and elevated CRP levels (OR: 1.8, 95% CI, 1.04-3.11, P = 0.02) were independently associated with anemia. The most common etiologies of anemia found in both groups were iron deficiency anemia (IDA; 10% on CD and 6% on UC) followed by the anemia of chronic disease (ACD; 6% for both groups).
In Brazilian IBD outpatients, anemia is highly concurrent condition. Disease moderate activity as well as increased CRP was strongly associated with comorbid anemia. IDA and/or ACD were the most common etiologies.
贫血在炎症性肠病（IBD）中很常见。然而，对非西方IBD人群的流行病学研究有限，且可能受到人口统计学、社会经济和疾病相关因素的影响。本研究评估了巴西IBD门诊患者贫血的患病率、危险因素和病因。
在这项横断面研究中，对100例克罗恩病（CD）患者和100例溃疡性结肠炎（UC）患者进行了评估。贫血检查包括全血细胞计数、铁蛋白、转铁蛋白饱和度、叶酸和维生素B12血清水平以及C反应蛋白（CRP）浓度。
IBD患者中贫血的总体患病率为21%。CD患者（24%）和UC患者（18%）的贫血患病率无显著差异。中度疾病活动（比值比：3.48，95%置信区间，1.95 - 9.64，P = 0.002）和CRP水平升高（比值比：1.8，95%置信区间，1.04 - 3.11，P = 0.02）与贫血独立相关。两组中发现的贫血最常见病因是缺铁性贫血（IDA；CD组为10%，UC组为6%），其次是慢性病贫血（ACD；两组均为6%）。
在巴西IBD门诊患者中，贫血是一种高度并发的病症。疾病中度活动以及CRP升高与合并贫血密切相关。IDA和/或ACD是最常见的病因。
