Jugan Maria C, Langston Cathy, Plattner Brandon L, Ford Alexandra K
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
J Vet Intern Med. 2025 May-Jun;39(3):e70131. doi: 10.1111/jvim.70131.
Iron deficiency in humans with chronic inflammatory enteropathies (CIE) is associated with active disease and anemia-related morbidity.
To compare iron deficiency prevalence in cats with CIE versus low-grade alimentary lymphoma (LGAL) and secondarily, determine the effect of iron deficiency on short-term clinical response in CIE cats.
Twenty-eight client-owned cats with primary gastrointestinal disease, including 14 CIE cats and 14 LGAL cats.
Prospective study. Cats were enrolled when they presented for gastrointestinal endoscopy. Iron panel (serum iron, ferritin, total iron binding capacity), CBC, cobalamin, serum amyloid A, methylmalonic acid, and clinical disease severity were evaluated. Cats were categorized as "normal" or "iron deficient" using calculated transferrin saturation. CIE cats were reevaluated 14, 30, and 90 days after initiation of non-standardized gastrointestinal disease treatment. Clinical response was compared based on iron and anemia status.
Iron deficiency was diagnosed in 7/28 cats (2/14 CIE, 5/14 LGAL cats) at enrollment and developed in four additional CIE cats during follow-up. While 9/28 cats were anemic at enrollment, neither anemia (relative risk [RR], 0.90; 95% confidence interval [CI], 0.13-5.50) nor iron status (RR, 0.4; 95% CI, 0.10-1.5) was associated with treatment response. Transferrin saturation was lower in LGAL cats (22%; 95% CI, 20%-27%) than in CIE cats (30%; 95% CI, 26%-39%).
There was high prevalence of iron deficiency over the first 90 days of treatment in CIE cats. Iron deficiency did not affect short-term response to individualized treatment of gastrointestinal disease.
患有慢性炎症性肠病（CIE）的人类缺铁与活动性疾病及贫血相关发病率有关。
比较患有CIE的猫与低度消化道淋巴瘤（LGAL）猫的缺铁患病率，其次，确定缺铁对CIE猫短期临床反应的影响。
28只客户拥有的患有原发性胃肠道疾病的猫，包括14只CIE猫和14只LGAL猫。
前瞻性研究。猫在进行胃肠内窥镜检查时入组。评估铁指标（血清铁、铁蛋白、总铁结合力）、全血细胞计数、钴胺素、血清淀粉样蛋白A、甲基丙二酸和临床疾病严重程度。使用计算得出的转铁蛋白饱和度将猫分为“正常”或“缺铁”。CIE猫在开始非标准化胃肠道疾病治疗后的14、30和90天进行重新评估。根据铁和贫血状况比较临床反应。
入组时28只猫中有7只（2只CIE猫，5只LGAL猫）被诊断为缺铁，另外4只CIE猫在随访期间出现缺铁。入组时28只猫中有9只贫血，但贫血（相对风险[RR]，0.90；95%置信区间[CI]，0.13 - 5.50）和铁状态（RR，0.4；95%CI，0.10 - 1.5）均与治疗反应无关。LGAL猫的转铁蛋白饱和度（22%；95%CI，20% - 27%）低于CIE猫（30%；95%CI，26% - 39%）。
CIE猫在治疗的前90天缺铁患病率较高。缺铁不影响胃肠道疾病个体化治疗的短期反应。
