痕量胺相关受体 1 在单胺转运体和多巴胺能活动的功能调节中的新兴作用。
The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.
机构信息
The New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA.
出版信息
J Neurochem. 2011 Jan;116(2):164-76. doi: 10.1111/j.1471-4159.2010.07109.x.
Abstract
It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity.
摘要
现在人们已经认识到，痕量胺相关受体 1（TAAR1）在调节大脑单胺类物质和介导安非他命类精神兴奋剂的作用方面发挥着功能作用。因此，对 TAAR1 的研究为开发治疗药物成瘾以及以大脑单胺类物质调节异常为特征的神经精神疾病的药物开辟了新途径。本综述重点介绍了最近的研究，这些研究揭示了 TAAR1 在单胺转运体的功能调节以及调节多巴胺能活动的神经元调节机制中的作用。
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