Institute of Psychiatry, King's College London, De Crespigny Park, London, United Kingdom.
Psychoneuroendocrinology. 2011 Jun;36(5):737-41. doi: 10.1016/j.psyneuen.2010.10.009. Epub 2010 Nov 11.
Magnetic resonance imaging (MRI) scans are a novel environment for most participants. The hypothalamic-pituitary-adrenal (HPA) axis modulates neurohormonal responses to novel and stressful experiences. We sought to examine the neurohormonal responses to MRI scans with the measurement of salivary cortisol. We examined: (1) acute effects of MRI scans by acquiring cortisol measurements immediately preceding and following the scan in comparison with basal cortisol levels, and (2) effects of novelty by measuring cortisol during repeated MRI scans in the same subjects. We examined these effects in two groups of subjects: healthy individuals (n=27, mean age 41.6 years) and patients with depression (n=24, mean age 40.0 years). Both groups showed elevated cortisol levels immediately preceding the MRI scan, particularly for the initial MRI scan, which normalised after the follow up MRI scans as compared with mean basal cortisol levels. There were no significant differences in the acute or mean basal cortisol levels between the groups. In summary, the MRI experience is stressful, particularly for the initial scan, but the stress response is reduced with subsequent scans.
磁共振成像（MRI）扫描对大多数参与者来说是一个新的环境。下丘脑-垂体-肾上腺（HPA）轴调节对新的和有压力的体验的神经激素反应。我们试图通过测量唾液皮质醇来检查 MRI 扫描的神经激素反应。我们检查了：（1）通过在扫描前后立即与基础皮质醇水平相比获得皮质醇测量值来检查 MRI 扫描的急性影响，以及（2）通过在相同受试者中重复 MRI 扫描时测量皮质醇来检查新奇感的影响。我们在两组受试者中检查了这些影响：健康个体（n=27，平均年龄 41.6 岁）和抑郁症患者（n=24，平均年龄 40.0 岁）。两组受试者在 MRI 扫描前皮质醇水平升高，尤其是对于初次 MRI 扫描，与平均基础皮质醇水平相比，在后续 MRI 扫描后恢复正常。两组之间在急性或平均基础皮质醇水平方面没有显著差异。总之，MRI 体验是有压力的，特别是对于初次扫描，但随着后续扫描，压力反应会减轻。
