Laboratório de Neuroquímica e Psicofarmacologia, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619-900 Porto Alegre, RS, Brazil.
Neurotoxicology. 2011 Jan;32(1):116-22. doi: 10.1016/j.neuro.2010.11.001. Epub 2010 Nov 11.
Pollution is a world problem with immeasurable consequences. Heavy metal compounds are frequently found as components of anthropogenic pollution. Here we evaluated the effects of the treatment with cadmium acetate, lead acetate, mercury chloride, and zinc chloride in acetylcholinesterase activity and gene expression pattern, as well as the effects of these treatments in antioxidant competence in the brain of an aquatic and well-established organism for toxicological analysis, zebrafish (Danio rerio, Cyprinidae). Mercury chloride and lead acetate promoted a significant decrease in acetylcholinesterase activity whereas they did not alter the gene expression pattern. In addition, the antioxidant competence was decreased after exposure to mercury chloride. The data presented here allowed us to hypothesize a signal transmission impairment, through alterations in cholinergic transmission, and also in the antioxidant competence of zebrafish brain tissue as some of the several effects elicited by these pollutants.
污染是一个具有不可估量后果的世界性问题。重金属化合物经常作为人为污染的组成部分被发现。在这里，我们评估了醋酸镉、醋酸铅、氯化汞和氯化锌处理对乙酰胆碱酯酶活性和基因表达模式的影响，以及这些处理对一种水生且已建立的毒理学分析生物——斑马鱼（Danio rerio，鲤科）大脑抗氧化能力的影响。氯化汞和醋酸铅显著降低了乙酰胆碱酯酶活性，而没有改变基因表达模式。此外，暴露于氯化汞后抗氧化能力下降。这里呈现的数据使我们假设通过改变胆碱能传递和斑马鱼脑组织的抗氧化能力，信号传递受到了损害，这是这些污染物引起的几种影响之一。
