Frisk V, Milner B
Department of Psychology, McGill University, Montreal, Quebec, Canada.
Neuropsychologia. 1990;28(2):121-35. doi: 10.1016/0028-3932(90)90095-6.
Patients undergoing unilateral temporal lobectomy were tested preoperatively for working memory capacity, sentence comprehension, and rapid-naming ability, and were retested on these same measures 3 to 5 days and 2 weeks postoperatively. Immediate recall of stories was assessed twice only: preoperatively, and 2 weeks postoperatively. The left temporal-lobe group demonstrated transient deficits in working memory capacity, sentence comprehension, and rapid-naming ability over the 2 week postoperative period. No significant group differences in working memory capacity were evident two weeks after operation, even though the story recall of the left temporal-lobe group was impaired. A second experiment, with additional patients, explored the possible contribution of the hippocampus and of the frontal lobes to performance on these same tasks. Extent of hippocampal excision did not affect performance differentially on any task. Story recall was impaired following left temporal lobectomy, whereas left frontal lobectomy impaired sentence comprehension and rapid-naming ability. These results indicate a double dissociation of verbal deficits 2 weeks after left temporal- and left frontal-lobe excisions.
对接受单侧颞叶切除术的患者在术前进行工作记忆能力、句子理解能力和快速命名能力测试，并在术后3至5天和2周对这些相同指标进行重新测试。对故事的即时回忆仅评估两次：术前和术后2周。左侧颞叶组在术后2周内表现出工作记忆能力、句子理解能力和快速命名能力的短暂缺陷。术后两周，尽管左侧颞叶组的故事回忆受损，但在工作记忆能力方面没有明显的组间差异。第二个实验纳入了更多患者，探讨了海马体和额叶对这些相同任务表现的可能贡献。海马体切除范围对任何任务的表现均无差异影响。左侧颞叶切除术后故事回忆受损，而左侧额叶切除术后句子理解能力和快速命名能力受损。这些结果表明，左侧颞叶和左侧额叶切除术后2周存在言语缺陷的双重分离。
