Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.
Brain Stimul. 2021 Jan-Feb;14(1):131-140. doi: 10.1016/j.brs.2020.11.015. Epub 2020 Dec 3.
While deep brain stimulation has been successful in treating movement disorders, such as in Parkinson's disease, its potential application in alleviating memory disorders is inconclusive.
OBJECTIVE/HYPOTHESIS: We investigated the role of the location of the stimulating electrode on memory improvement and hypothesized that entorhinal white versus gray matter stimulation would have differential effects on memory.
Intracranial electrical stimulation was applied to the entorhinal area of twenty-two participants with already implanted electrodes as they completed visual memory tasks.
We found that stimulation of right entorhinal white matter during learning had a beneficial effect on subsequent memory, while stimulation of adjacent gray matter or left-sided stimulation was ineffective. This finding was consistent across three different visually guided memory tasks.
Our results highlight the importance of precise stimulation site on modulation of human hippocampal-dependent memory and suggest that stimulation of afferent input into the right hippocampus may be an especially promising target for enhancement of visual memory.
尽管深度脑刺激在治疗运动障碍方面已取得成功，例如在帕金森病中，但它在缓解记忆障碍方面的应用尚无定论。
目的/假设：我们研究了刺激电极位置对记忆改善的作用，并假设内嗅皮质白质与灰质刺激对记忆会产生不同的影响。
当 22 名已经植入电极的参与者完成视觉记忆任务时，我们对其内嗅区进行颅内电刺激。
我们发现，学习过程中右侧内嗅白质刺激对后续记忆有有益影响，而相邻灰质刺激或左侧刺激则无效。这一发现与三种不同的视觉引导记忆任务一致。
我们的结果强调了精确刺激部位对人类海马依赖记忆调节的重要性，并表明刺激传入右侧海马的输入可能是增强视觉记忆的一个特别有前途的目标。
