Department of Biosystems Science and Engineering, ETH Zurich, CH-4058 Basel, Switzerland.
Dev Cell. 2010 Nov 16;19(5):651-61. doi: 10.1016/j.devcel.2010.10.012.
The Polycomb group (PcG) system represses the transcription of important developmental regulators and perpetuates this repression across multiple cell divisions. Inputs from outside the cell can influence PcG function by recruiting additional chromatin factors to PcG-regulated loci or by downregulating the PcG genes themselves. These types of PcG system modulation allow context-dependent induction of genes during development, in cancer, and in response to changes in the environment. In this review, we outline instances where molecular players in this process have been recently identified, comparing and contrasting different ways in which derepression is achieved, and projecting directions for future research.
多梳抑制复合物（PcG）系统抑制重要发育调控因子的转录，并使其在多个细胞分裂中保持这种抑制状态。细胞外的输入可以通过招募额外的染色质因子到 PcG 调控的基因座，或者通过下调 PcG 基因本身，来影响 PcG 功能。这些类型的 PcG 系统调节允许在发育过程中、在癌症中以及在响应环境变化时，对基因进行上下文相关的诱导。在这篇综述中，我们概述了最近在这个过程中确定的分子参与者的实例，比较和对比了不同的去抑制方式，并为未来的研究提出了方向。
