Tongji University, Shanghai, PR China.
Chemosphere. 2011 Feb;82(7):1024-9. doi: 10.1016/j.chemosphere.2010.10.063. Epub 2010 Nov 12.
Ionic liquids (ILs) are a fascinating group of new chemicals with the potential to replace the classical volatile organic solvents, stimulating many applications in chemical industry. In case ILs are released to the environment, possible combined toxicity should be taken into account and it is, however, often neglected up to now. In this paper, therefore, the concentration-response curves (CRCs) of four groups of IL mixtures with various mixture ratios to Vibrio qinghaiensis sp.-Q67 were determined using the microplate toxicity analysis and were compared to the CRCs predicted by an additive reference model, the concentration addition (CA) or independent action (IA), to identify the toxicity interaction. It is showed that most of the IL mixture rays displayed the classical addition while the remaining rays exhibited antagonism or synergism. Moreover, it is found that the pEC₅₀ values of the mixture rays exhibiting antagonism or synergism are well correlated with the mixture ratio of a certain IL therein.
离子液体（ILs）是一类引人入胜的新型化学品，具有替代传统挥发性有机溶剂的潜力，刺激了化学工业的许多应用。如果 ILs 被释放到环境中，可能的联合毒性应该被考虑到，但迄今为止这往往被忽视。因此，本文采用微孔板毒性分析方法，确定了四组不同混合比例的 IL 混合物对青海弧菌 sp.-Q67 的浓度-反应曲线（CRC），并与浓度加和（CA）或独立作用（IA）的加和参考模型预测的 CRC 进行了比较，以确定毒性相互作用。结果表明，大多数 IL 混合物射线表现出经典的加和作用，而其余射线表现出拮抗或协同作用。此外，还发现表现出拮抗或协同作用的混合物射线的 pEC₅₀ 值与其中某一 IL 的混合物比例密切相关。
