CMRR d'Aquitaine, CHU Bordeaux, Bordeaux, France.
Neurobiol Aging. 2012 Feb;33(2):423.e15-25. doi: 10.1016/j.neurobiolaging.2010.09.023. Epub 2010 Nov 12.
The influence of education, occupation, and leisure activities on the passive and active components of reserve capacity remains unclear. We used the voxel-based morphometry (VBM) technique in a population-based sample of 331 nondemented people in order to investigate the relationship between these factors and the cerebral volume (a marker of brain reserve). The results showed a positive and significant association between education, occupation, and leisure activities and the cognitive performances on Isaac's set test. Among these factors, only education was significantly associated with a cerebral volume including gray and white matter (p = 0.01). In voxel-based morphometry analyses, the difference in gray matter volume was located in the temporoparietal lobes and in the orbitofrontal lobes bilaterally (a p-value corrected <0.05 by false discovery rate [FDR]). Although smaller, the education-related difference in white matter volume appeared in areas connected to the education-related difference in gray matter volume. Education, occupation attainment, and leisure activities were found to contribute differently to reserve capacity. Education could play a role in the constitution of cerebral reserve capacity.
教育、职业和休闲活动对储备能力的被动和主动成分的影响尚不清楚。我们使用基于体素的形态测量学（VBM）技术，对 331 名非痴呆人群进行了一项基于人群的样本研究，以调查这些因素与大脑体积（脑储备的标志物）之间的关系。结果表明，教育、职业和休闲活动与艾萨克成套测验的认知表现呈正相关且显著相关。在这些因素中，只有教育与包括灰质和白质在内的脑体积显著相关（p = 0.01）。在基于体素的形态测量学分析中，灰质体积的差异位于双侧颞顶叶和眶额叶（通过虚假发现率 [FDR] 校正的 p 值<0.05）。尽管较小，但与教育相关的白质体积差异出现在与灰质体积差异相关的区域。研究发现，教育、职业成就和休闲活动对储备能力的贡献不同。教育可能在脑储备能力的构成中发挥作用。
