Division of Pediatric Cardiology, Laval University Hospital Centre, Faculty of Medicine, Laval University, Quebec, Quebec, Canada.
J Am Soc Echocardiogr. 2011 Jan;24(1):60-74. doi: 10.1016/j.echo.2010.10.004. Epub 2010 Nov 13.
The aim of this study was to find the best model to obtain valid and normally distributed Z scores for coronary artery (CA) diameters in a large, heterogeneous population of healthy children.
Echocardiography was performed on 1,033 healthy children. Several regression models were tested with height, weight, body surface area, and aortic valve diameter. The computed Z scores were tested for normal distribution and stability.
CA diameter was best predicted using regression with the square root of body surface area. The weighted least squares method yielded normally distributed and very stable Z-score estimates for all CA segments. In prepubertal children, aortic valve diameter was also a valid predictor of CA diameter.
This study shows two valid methods to estimate Z scores for CA size in children of all ages. Such Z scores are important for risk stratification in patients with Kawasaki disease.
本研究旨在为大样本异质健康儿童的冠状动脉（CA）直径寻找最佳模型，以获得有效且正态分布的 Z 分数。
对 1033 名健康儿童进行超声心动图检查。使用身高、体重、体表面积和主动脉瓣直径测试了几种回归模型。对计算出的 Z 分数进行正态分布和稳定性检验。
使用体表面积的平方根进行回归可以最好地预测 CA 直径。加权最小二乘法为所有 CA 节段生成了正态分布且非常稳定的 Z 分数估计值。在青春期前儿童中，主动脉瓣直径也是 CA 直径的有效预测因子。
本研究表明了两种有效方法，可以估算所有年龄段儿童 CA 大小的 Z 分数。在川崎病患者中，此类 Z 分数对于风险分层很重要。
