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川崎病伴持续性严重银屑病样皮肤表现及心源性猝死

Kawasaki disease with persistent severe psoriatic-like skin manifestations and sudden cardiac death.

作者信息

Salih Aso F, Qadir Trifa M, Dahdah Nagib

机构信息

Department of Clinical Science, College of Medicine, Sulaimani University, Sulaimani, Iraq.

Department of Pediatric Cardiology, Anwar Shexa Medical City, Qaiwan International University, Kurdistan Region, Sulaimanya, Iraq.

出版信息

Int J Cardiol Congenit Heart Dis. 2025 Jun 26;21:100604. doi: 10.1016/j.ijcchd.2025.100604. eCollection 2025 Sep.

Abstract

This case report describes a 1.3-year-old infant with an atypical presentation of Kawasaki Disease (KD) following exposure to COVID-19 within the family and positive SARS-CoV-2 IgG antibodies. The clinical course was marked by significant left ventricular (LV) dysfunction, progressive coronary artery involvement, and complicated by severe dermatologic manifestations including Steven-Johnson-like lesions and psoriatic-like eruptions. Despite initial improvement in cardiac function, the infant developed multiple coronary aneurysms and succumbed to sudden cardiac death. This case highlights the diagnostic and therapeutic challenges in managing atypical KD in the context of COVID-19. We describe the case and review the literature related to the associated severe skin lesions.

摘要

本病例报告描述了一名1.3岁婴儿,在家庭中接触新冠病毒(COVID-19)且严重急性呼吸综合征冠状病毒2(SARS-CoV-2)IgG抗体呈阳性后,出现了不典型的川崎病(KD)表现。临床过程的特征为显著的左心室(LV)功能障碍、进行性冠状动脉受累,并伴有严重的皮肤表现,包括史蒂文斯-约翰逊综合征样病变和银屑病样皮疹。尽管心脏功能最初有所改善,但该婴儿仍出现了多个冠状动脉瘤,并最终死于心源性猝死。本病例突出了在COVID-19背景下管理不典型KD时的诊断和治疗挑战。我们描述了该病例,并回顾了与相关严重皮肤病变有关的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5f/12271588/530f3a7a6826/gr1.jpg

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