Cell Biology Program, Hospital for Sick Children, 555 University Ave., Toronto M5G 1X8, Canada.
Curr Opin Cell Biol. 2011 Feb;23(1):22-9. doi: 10.1016/j.ceb.2010.10.006. Epub 2010 Nov 11.
Particle engulfment during phagocytosis has long been appreciated to be an active, actin-driven process. By contrast, the preceding stage--securing the target to the surface of the phagocyte--was thought to result from the passive diffusion of receptors along the membrane towards their ligands on the particle surface. Recent evidence, however, challenges this notion, demonstrating that receptors do not diffuse freely along the phagocyte surface and that actin polymerization and tyrosine phosphorylation are required for optimal particle binding. The interpretation and significance of these observations are the subject of this opinion piece.
吞噬作用过程中的颗粒吞噬一直被认为是一个主动的、肌动蛋白驱动的过程。相比之下，之前的阶段——将目标物固定到吞噬细胞表面——被认为是受体沿着细胞膜被动扩散到颗粒表面的配体上的结果。然而，最近的证据挑战了这一观点，表明受体不能沿着吞噬细胞表面自由扩散，并且肌动蛋白聚合和酪氨酸磷酸化是最佳颗粒结合所必需的。本文对这些观察结果的解释和意义进行了讨论。
