Sandvig Kirsten, Iversen Tore Geir, Skotland Tore
Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, 0379 Oslo, Norway.
Centre for Cancer Cell Reprogramming, University of Oslo, 0379 Oslo, Norway.
Beilstein J Nanotechnol. 2024 Aug 12;15:1017-1029. doi: 10.3762/bjnano.15.83. eCollection 2024.
In this article we discuss how nanoparticles (NPs) of different compositions may interact with and be internalized by cells, and the consequences of that for cellular functions. A large number of NPs are made with the intention to improve cancer treatment, the goal being to increase the fraction of injected drug delivered to the tumor and thereby improve the therapeutic effect and decrease side effects. Thus, we discuss how NPs are delivered to tumors and some challenges related to investigations of biodistribution, pharmacokinetics, and excretion. Finally, we discuss requirements for bringing NPs into clinical use and aspects when it comes to usage of complex and slowly degraded or nondegradable NPs.
在本文中，我们讨论了不同成分的纳米颗粒（NPs）如何与细胞相互作用并被细胞内化，以及这对细胞功能的影响。大量纳米颗粒的制备旨在改善癌症治疗，目标是增加注射药物输送到肿瘤的比例，从而提高治疗效果并减少副作用。因此，我们讨论了纳米颗粒如何输送到肿瘤以及与生物分布、药代动力学和排泄研究相关的一些挑战。最后，我们讨论了将纳米颗粒投入临床使用的要求以及涉及复杂且降解缓慢或不可降解纳米颗粒使用的方面。
