Molécules de Communication et Adaptation des Micro-Organismes, FRE 3206 CNRS/MNHN, Muséum National d'Histoire Naturelle, 57 rue Cuvier, 75005 Paris, France.
J Ethnopharmacol. 2011 Jan 27;133(2):850-5. doi: 10.1016/j.jep.2010.11.013. Epub 2010 Nov 11.
In Uganda, malaria is the most common disease and Ugandan people largely rely on traditional medicine. In this context, we carried out an ethnobotanical study on the Kiohima village, located close to the Kibale National Park in South-Western Uganda and investigated in vitro the antiplasmodial and cytotoxic activities of selected medicinal plants.
Seventy-five plants-using adults (men and women) were interviewed to find out their plant use. From these information, 48 plants used in traditional medicine were identified and according to their reported uses and to bibliographic data, several parts of 28 plants (leaves, barks, roots), were selected and collected for biological evaluations. These samples were dried, extracted with ethyl acetate and the crude extracts were assayed for in vitro antiplasmodial and cytotoxic activities at 10 μg/mL.
One third of the screened plants showed a significant antiplasmodial activity with inhibition greater than 50% at 10 μg/mL.
These results may indicate a possible explanation of the use of some medicinal plant against malaria in the village of Kiohima and have also allowed to highlight a plant with potent antimalarial activity: Citropsis articulata root barks.
在乌干达，疟疾是最常见的疾病，乌干达人主要依赖传统医学。在这种情况下，我们对位于乌干达西南部靠近基巴莱国家公园的基奥希马村进行了民族植物学研究，并对选定的药用植物进行了体外抗疟原虫和细胞毒性活性研究。
对 75 名（男女）植物使用成年人进行访谈，以了解他们的植物使用情况。根据这些信息，确定了 48 种用于传统医学的植物，根据其报告的用途和文献数据，选择了 28 种植物的几个部分（叶子、树皮、根）进行收集和生物评价。这些样品经过干燥、用乙酸乙酯提取，然后在 10μg/mL 下测定粗提取物的体外抗疟原虫和细胞毒性活性。
三分之一的筛选植物表现出显著的抗疟原虫活性，在 10μg/mL 时抑制率大于 50%。
这些结果可能表明基奥希马村一些药用植物用于治疗疟疾的原因，同时也突出了一种具有强大抗疟活性的植物：Citropsis articulata 根皮。
