环丙沙星致尖端扭转型室性心动过速。

Ciprofloxacin-induced torsade de pointes.

机构信息

Division of Cardiology, University of South Alabama, Mobile, AL, USA.

出版信息

Am J Emerg Med. 2012 Jan;30(1):252.e5-9. doi: 10.1016/j.ajem.2010.09.039. Epub 2010 Nov 13.

DOI:10.1016/j.ajem.2010.09.039

Abstract

A 65-year-old man with recently diagnosed urinary tract infection treated with ciprofloxacin (Cipro) presented to our institution with recurrent seizure-like activity. His rhythm revealed torsade de pointes, which required defibrillation. Subsequent electrocardiogram revealed severely prolonged QT interval, which near-completely resolved 7 days later off Cipro. This case highlights a rare but potentially fatal side effect of quinolone antibiotics, especially in combination with other QT-prolonging medications. Review of the literature with regard to prevalence, mechanism, and assessment and treatment of this potentially fatal incidence is provided.

摘要

一位 65 岁的男性，近期诊断为尿路感染，接受环丙沙星（Cipro）治疗，因反复出现类似癫痫发作的活动而到我院就诊。他的心律显示尖端扭转型室性心动过速（TdP），需要除颤。随后的心电图显示 QT 间期显著延长，停药 7 天后基本恢复正常。该病例突出了氟喹诺酮类抗生素的一种罕见但潜在致命的副作用，特别是与其他延长 QT 间期的药物联合使用时。本文对该潜在致命事件的发生率、发生机制、评估和治疗进行了文献回顾。