Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
J Microbiol Immunol Infect. 2010 Oct;43(5):360-5. doi: 10.1016/S1684-1182(10)60057-6.
BACKGROUND/PURPOSE: Parainfluenza viruses (PIVs) are common pathogens in respiratory tract infections. The aims of this study were to determine the clinical presentation of PIV infections in hospitalized children and to identify particular clinical indications that may effectively distinguish between different PIV serotypes.
A retrospective review of data from children hospitalized with PIV infections at the Mackay Memory Hospital in Taipei between January 2005 and December 2007 was undertaken. Symptoms, signs, laboratory findings and seasonal variations between different types of PIV (serotypes 1, 2 and 3) were compared.
A total of 206 patients [119 (57.8%) boys and 87 (42.2%) girls] were enrolled in the study. Seventy-four (35.9%) patients were infected with PIV serotype 1, 25 (12.1%) with serotype 2 and 107 (51.9%) with serotype 3. The most common clinical presentations were fever (81.1%), cough (66.0%), rhinorrhea (44.2%) and hoarseness (22.3%); 4.9% of the infected children also had skin rashes. No significant differences were found in average white blood cell counts and C-reactive protein levels between the three serotypes. PIV serotype 1 infections were discernible throughout the year; serotype 2 tended to cluster in the late summer and autumn of 2005 and 2007; and serotype 3 was more common in the spring and early summer.
The clinical presentation of PIV infection in hospitalized children ranges from upper respiratory tract infection to croup, bronchiolitis and viral bronchopneumonia, with the different types of PIV infections giving rise to similar symptoms. The seasonal distribution of the different serotypes is, nevertheless, quite distinct.
背景/目的：副流感病毒（PIV）是呼吸道感染的常见病原体。本研究旨在确定住院儿童的 PIV 感染临床表现，并确定可能有效区分不同 PIV 血清型的特定临床指征。
对 2005 年 1 月至 2007 年 12 月期间在台北马偕纪念医院住院的 PIV 感染患儿的病历进行回顾性分析。比较了不同类型 PIV（血清型 1、2 和 3）的症状、体征、实验室检查结果和季节性差异。
共纳入 206 例患儿[男 119 例（57.8%），女 87 例（42.2%）]。74 例（35.9%）患儿感染 PIV 血清型 1，25 例（12.1%）感染血清型 2，107 例（51.9%）感染血清型 3。最常见的临床表现为发热（81.1%）、咳嗽（66.0%）、流涕（44.2%）和声音嘶哑（22.3%）；4.9%的感染患儿还有皮疹。三种血清型的白细胞计数和 C 反应蛋白水平平均无显著差异。PIV 血清型 1 感染全年均可发生；血清型 2 倾向于 2005 年和 2007 年夏末和秋季聚集；血清型 3 则多见于春季和初夏。
住院儿童的 PIV 感染临床表现从上呼吸道感染到哮吼、细支气管炎和病毒性支气管肺炎不等，不同类型的 PIV 感染引起相似的症状。然而，不同血清型的季节性分布截然不同。
