Ariño Joaquín, Casamayor Antonio, González Asier
Departament de Bioquímica i Biologia Molecular, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès 08193, Barcelona, Spain.
Eukaryot Cell. 2011 Jan;10(1):21-33. doi: 10.1128/EC.00249-10. Epub 2010 Nov 12.
Type 2C Ser/Thr phosphatases are a remarkable class of protein phosphatases, which are conserved in eukaryotes and involved in a large variety of functional processes. Unlike in other Ser/Thr phosphatases, the catalytic polypeptide is not usually associated with regulatory subunits, and functional specificity is achieved by encoding multiple isoforms. For fungi, most information comes from the study of type 2C protein phosphatase (PP2C) enzymes in Saccharomyces cerevisiae, where seven PP2C-encoding genes (PTC1 to -7) with diverse functions can be found. More recently, data on several Candida albicans PP2C proteins became available, suggesting that some of them can be involved in virulence. In this work we review the available literature on fungal PP2Cs and explore sequence databases to provide a comprehensive overview of these enzymes in fungi.
2C型丝氨酸/苏氨酸磷酸酶是一类非凡的蛋白质磷酸酶，在真核生物中保守，参与多种功能过程。与其他丝氨酸/苏氨酸磷酸酶不同，催化多肽通常不与调节亚基相关联，而是通过编码多种同工型来实现功能特异性。对于真菌，大多数信息来自对酿酒酵母中2C型蛋白磷酸酶（PP2C）酶的研究，在那里可以发现七个具有不同功能的PP2C编码基因（PTC1至-7）。最近，关于几种白色念珠菌PP2C蛋白的数据也已获得，这表明其中一些可能与毒力有关。在这项工作中，我们回顾了有关真菌PP2C的现有文献，并探索了序列数据库，以全面概述真菌中的这些酶。
