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FcRav2, a gene with a ROGDI domain involved in Fusarium head blight and crown rot on durum wheat caused by Fusarium culmorum.FcRav2，一个含 ROGDI 结构域的基因，与禾谷镰刀菌引起的硬粒小麦赤霉病和冠腐病有关。
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8
A type 2C protein phosphatase FgPtc3 is involved in cell wall integrity, lipid metabolism, and virulence in Fusarium graminearum.2C 型蛋白磷酸酶 FgPtc3 参与了禾谷镰刀菌细胞壁完整性、脂类代谢和毒性。
PLoS One. 2011;6(9):e25311. doi: 10.1371/journal.pone.0025311. Epub 2011 Sep 28.
9
Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB.结核分枝杆菌丝氨酸/苏氨酸磷酸酶由 PknA 和 PknB 磷酸化。
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Type 2C protein phosphatases in fungi.真菌中的2C型蛋白磷酸酶。
Eukaryot Cell. 2011 Jan;10(1):21-33. doi: 10.1128/EC.00249-10. Epub 2010 Nov 12.

本文引用的文献

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Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1.酵母TOR信号通路的正常功能需要2C型蛋白磷酸酶Ptc1。
Mol Cell Biol. 2009 May;29(10):2876-88. doi: 10.1128/MCB.01740-08. Epub 2009 Mar 9.
2
Characterization of Fusarium graminearum isolates resistant to both carbendazim and a new fungicide JS399-19.对多菌灵和新型杀菌剂JS399-19均具有抗性的禾谷镰刀菌分离株的特性分析
Phytopathology. 2009 Apr;99(4):441-6. doi: 10.1094/PHYTO-99-4-0441.
3
Sexual recombination of carbendazim resistance in Fusarium graminearum under field conditions.禾谷镰刀菌对多菌灵抗性在田间条件下的有性重组
Pest Manag Sci. 2009 Apr;65(4):398-403. doi: 10.1002/ps.1704.
4
PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex.液泡遗传需要PTC1，并且PTC1能促进肌球蛋白-V液泡特异性受体复合物的结合。
Mol Biol Cell. 2009 Mar;20(5):1312-23. doi: 10.1091/mbc.e08-09-0954. Epub 2008 Dec 30.
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A serine/threonine protein phosphatase-like protein, CaPTC8, from Candida albicans defines a new PPM subfamily.来自白色念珠菌的一种丝氨酸/苏氨酸蛋白磷酸酶样蛋白CaPTC8定义了一个新的PPM亚家族。
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Economic and social impacts of fusarium head blight: changing farms and rural communities in the northern great plains.镰刀菌头腐病的经济和社会影响：大平原北部不断变化的农场和农村社区
Phytopathology. 2000 Jan;90(1):17-21. doi: 10.1094/PHYTO.2000.90.1.17.
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Identification of the putative protein phosphatase gene PTC1 as a virulence-related gene using a silkworm model of Candida albicans infection.利用白色念珠菌感染家蚕模型鉴定推定的蛋白磷酸酶基因PTC1作为毒力相关基因。
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Characterization and fitness of carbendazim-resistant strains of Fusarium graminearum (wheat scab).禾谷镰刀菌（小麦赤霉病）多菌灵抗性菌株的特性及适应性
Pest Manag Sci. 2007 Dec;63(12):1201-7. doi: 10.1002/ps.1449.
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The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.禾谷镰刀菌基因组揭示了局部多态性与病原体特化之间的联系。
Science. 2007 Sep 7;317(5843):1400-2. doi: 10.1126/science.1143708.
10
Epidemiology of Fusarium head blight on small-grain cereals.小粒谷物赤霉病的流行病学
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植物病原真菌禾谷镰刀菌的 2C 型蛋白磷酸酶 FgPtc1p 参与锂毒性和毒力。

The type 2C protein phosphatase FgPtc1p of the plant fungal pathogen Fusarium graminearum is involved in lithium toxicity and virulence.

机构信息

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China.

出版信息

Mol Plant Pathol. 2010 Mar;11(2):277-82. doi: 10.1111/j.1364-3703.2009.00598.x.

DOI:10.1111/j.1364-3703.2009.00598.x
PMID:20447276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6640505/
Abstract

Type 2C protein phosphatases (PP2Cs) are monomeric protein serine/threonine phosphatases that play various roles in eukaryotic organisms. In this study, we characterized the PP2C encoded by FgPTC1 in Fusarium graminearum, the major causal agent of Fusarium head blight on wheat and barley. We found that deletion of FgPTC1 delays the mycelium growth of F. graminearum in response to lithium. Consistently, FgPTC1 complemented the function of ScPTC1 in lithium toxicity in Saccharomyces cerevisiae. Furthermore, we showed that deletion of FgPTC1 attenuated the virulence of F. graminearum on wheat. Therefore, FgPTC1 plays an important role in regulating the hyphal growth and virulence of F. graminearum.

摘要

2C 型蛋白磷酸酶（PP2Cs）是单体蛋白丝氨酸/苏氨酸磷酸酶，在真核生物中发挥多种作用。在本研究中，我们对禾谷镰孢中由 FgPTC1 编码的 PP2C 进行了表征，禾谷镰孢是小麦和大麦赤霉病的主要病原体。我们发现，FgPTC1 的缺失会延迟禾谷镰孢菌丝对锂的生长响应。一致地，FgPTC1 互补了酿酒酵母中 ScPTC1 在锂毒性中的功能。此外，我们表明，FgPTC1 的缺失削弱了禾谷镰孢对小麦的毒性。因此，FgPTC1 在调节禾谷镰孢菌丝生长和毒性方面发挥着重要作用。