硫脲与大鼠肺蛋白的相互作用。
Interaction of thiourea with rat lung protein.
作者信息
Hollinger M A, Giri S N
机构信息
Department of Pharmacology, School of Medicine, School of Veterinary Medicine University of California, Davis 95616.
出版信息
Toxicology. 1990 Mar 16;60(3):245-51. doi: 10.1016/0300-483x(90)90147-9.
PMID:2107604
Abstract
Administration of the pulmonary edemagenic agent [14C]Thiourea [( 14C]TU) to adult rats results in heterogeneous binding to lung protein. Indirect evidence suggests that TU may be binding to the amino acid cysteine, possibly via the SH moiety. The nature of the adduct is not known, but appears to involve one major and several minor species.
摘要
给成年大鼠注射肺水肿原剂[14C]硫脲[（14C）TU]会导致其与肺蛋白的结合不均匀。间接证据表明，TU可能通过SH基团与氨基酸半胱氨酸结合。加合物的性质尚不清楚，但似乎涉及一个主要物种和几个次要物种。
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