Falk S, Mix D, Stutte H J
Department of Pathology, J.W. Goethe University Frankfurt, West Germany.
Virchows Arch A Pathol Anat Histopathol. 1990;416(5):437-42. doi: 10.1007/BF01605150.
30 spleens from patients with biopsy proven primary osteomyelofibrosis were studied by histological and immunohistochemical methods. The presence of trilinear haematopoiesis along the splenic circulatory pathway supports the theory that the spleen acquires haematopoietic precursor cells by filtration of the peripheral blood. In addition, impairment of intrasplenic circulation with subsequent red pulp congestion, pulp cord fibrosis and haemophagocytosis is of importance for the pathogenesis of both marked splenic haematopoiesis and complications due to hypersplenism.
通过组织学和免疫组化方法对30例经活检证实为原发性骨髓纤维化患者的脾脏进行了研究。脾脏循环途径中三系造血的存在支持了脾脏通过过滤外周血获取造血前体细胞的理论。此外，脾内循环受损伴随后的红髓充血、髓索纤维化和噬血细胞现象对于显著的脾造血和脾功能亢进并发症的发病机制都很重要。
