Department of Applied Mathematics, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.
J Clin Neurophysiol. 2010 Dec;27(6):471-8. doi: 10.1097/WNP.0b013e3181fe0735.
Two models of the neocortex are developed to study normal and pathologic neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons, and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar, synchronized behavior in this detailed model. This observation is captured by a population model that describes the activity of large neuronal populations with two differential equations with two delays. Both models appear to have similar sensitivity to variations of total network excitation. Analysis of the population model reveals the presence of multistability, which was also observed in various simulations of the detailed model.
开发了两种新皮层模型来研究正常和病理神经元活动。一个模型包含了一个由 656 个神经元组成的新皮层微柱的详细描述，包括浅层和深层锥体神经元、四种抑制性神经元和现实的突触接触。模拟表明，在这个详细的模型中，给定类型的神经元表现出相似的、同步的行为。这种观察结果被一个群体模型所捕捉，该模型用两个具有两个时滞的微分方程来描述大神经元群体的活动。这两个模型对网络总兴奋度变化的敏感性似乎相似。对群体模型的分析揭示了多稳定性的存在，这种现象在详细模型的各种模拟中也观察到了。
