Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06410, USA.
Kidney Int. 2010 Dec;78(11):1060-3. doi: 10.1038/ki.2010.344.
Tenofovir, used in combination with other antiretroviral agents, is an effective therapy for HIV infection. Although large clinical studies and post-marketing data support a benign renal profile for tenofovir, numerous cases of kidney injury raise concern for nephrotoxic potential. Early human studies and experimental evidence suggested that tenofovir itself was not associated with mitochondrial toxicity within the kidney. However, recent animal data demonstrate that tenofovir causes mitochondrial DNA depletion and mitochondrial toxicity. Herlitz et al. confirm the nephrotoxicity of tenofovir in humans. They describe its clinical consequences, histopathologic findings, and its mitochondrial toxicity in HIV+ patients.
替诺福韦与其他抗逆转录病毒药物联合使用，是一种有效的 HIV 感染治疗方法。虽然大型临床研究和上市后数据支持替诺福韦具有良性的肾脏特征，但许多肾脏损伤的病例引起了人们对其潜在肾毒性的关注。早期的人体研究和实验证据表明，替诺福韦本身与肾脏的线粒体毒性无关。然而，最近的动物数据表明，替诺福韦会导致线粒体 DNA 耗竭和线粒体毒性。Herlitz 等人证实了替诺福韦在人类中的肾毒性。他们描述了其在 HIV 阳性患者中的临床后果、组织病理学发现和线粒体毒性。
