He Tianmu, Ao Jingwen, Duan Cancan, Yan Rong, Li Xiaomei, Liu Liu, Zhang Jianyong, Li Xiaofei
School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.
School of Basic Medical Sciences, Zunyi Medical University, Zunyi, China.
Front Pharmacol. 2022 Sep 14;13:940791. doi: 10.3389/fphar.2022.940791. eCollection 2022.
Nephrotoxicity of drugs contributes to acute kidney injury with high mortality and morbidity, which crucially limits the application and development of drugs. Although many publications on nephrotoxicity have been conducted globally, there needs to be a scientometric study to systematically analyze the intellectual landscape and frontiers research trends in the future. Publications on nephrotoxicity from 2011 to 2021 were collected to perform bibliometric visualization using VOSviewer, CiteSpace, and Scimago Graphica software based on the Web of Science Core Collection. A total of 9,342 documents were analyzed, which were primarily published in the United States (1,861), China (1,724), and Egypt (701). For institutions, King Saud University (166) had the most publications; Food and Chemical Toxicology, PLOS One, and Antimicrobial Agents and Chemotherapy were productive journals, primarily concentrating on the mechanisms of nephrotoxicity and renoprotective in cisplatin and antibiotics, especially in oxidative stress. Burst detection suggested that cisplatin, piperacillin-tazobactam, vancomycin-induced nephrotoxicity, antioxidants, and new biomaterials are frontiers of research. This study first provides an updated perspective on nephrotoxicity and renoprotective strategies and mechanisms. This perspective may benefit researchers in choosing suitable journals and collaborators and assisting them in the deep understanding of the nephrotoxicity and renoprotective hotspots and frontiers.
药物肾毒性会导致急性肾损伤，死亡率和发病率都很高，这严重限制了药物的应用和开发。尽管全球范围内已经发表了许多关于肾毒性的文献，但仍需要进行一项科学计量学研究，以系统地分析未来的学术格局和前沿研究趋势。收集了2011年至2021年期间关于肾毒性的文献，使用VOSviewer、CiteSpace和基于科学网核心合集的Scimago Graphica软件进行文献计量可视化分析。共分析了9342篇文献，这些文献主要发表在美国（1861篇）、中国（1724篇）和埃及（701篇）。在机构方面，沙特国王大学发表的文献最多（166篇）；《食品与化学毒理学》《公共科学图书馆·综合》以及《抗菌药物与化疗》是高产期刊，主要集中在顺铂和抗生素肾毒性的机制以及肾保护方面，尤其是氧化应激方面。突发检测表明，顺铂、哌拉西林-他唑巴坦、万古霉素诱导的肾毒性、抗氧化剂和新型生物材料是研究前沿。本研究首次提供了关于肾毒性及肾保护策略和机制的最新观点。这一观点可能有助于研究人员选择合适的期刊和合作伙伴，并帮助他们深入了解肾毒性和肾保护的热点及前沿。
