Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Kidney Int. 2010 Dec;78(11):1065-7. doi: 10.1038/ki.2010.364.
There is increasing evidence that alkali therapy can retard progression of chronic kidney disease (CKD). We summarize recent studies and discuss a mechanism whereby alkali therapy may neutralize acid production associated with typical Western diets, which generate acid. We emphasize the rationale for using alkali therapy early in the course of CKD, even in the absence of overt metabolic acidosis, and we urge the pharmaceutical industry to develop palatable alkali-containing solutions.
越来越多的证据表明，碱化疗法可以延缓慢性肾脏病（CKD）的进展。我们总结了最近的研究，并讨论了碱化疗法可能中和与典型西方饮食相关的酸性产生的机制，这种饮食会产生酸性。我们强调了在 CKD 早期，甚至在没有明显代谢性酸中毒的情况下，使用碱化疗法的基本原理，并敦促制药行业开发可口的含碱溶液。
