Pérez-López F R
Department of Obstetrics and Gynecology, Hospital Clinico Universitario, University of Zaragoza Faculty of Medicine, Spain.
Acta Endocrinol (Copenh). 1990 Feb;122(2):163-7.
Twelve untreated cycling women and 45 women using oral contraceptives were challenged iv with 50 micrograms of GnRH and 100 micrograms of TRH at 0, 90 and 180 min. The LH responses after the second and third pulses of GnRH/TRH were diminished in women treated with 30 micrograms of ethinylestradiol and levonorgestrel as compared with the control group, whereas the responses were severely blunted after each dose of GnRH/TRH in women treated with 50 micrograms of ethinylestradiol and levonorgestrel or lynestrenol as compared with both the control group and the women treated with 30 micrograms of ethinylestradiol and levonorgestrel. The FSH responses to GnRH/TRH in women treated with 30 micrograms of ethinylestradiol and levonorgestrel were similar to those in the control group, whereas there were reductions in the responses obtained in women treated with 50 micrograms of ehinylestradiol and progestin as compared with both the control group and the women under 30 micrograms of ethinylestradiol and levonorgestrel. In women treated with 30 micrograms of ethinylestradiol and levonorgestrel, the PRL peaks after the second and third pulses were higher than the first, and higher than the values obtained in the remaining three groups.
12名未接受治疗的处于月经周期的女性和45名使用口服避孕药的女性在0、90和180分钟时静脉注射50微克促性腺激素释放激素（GnRH）和100微克促甲状腺激素释放激素（TRH）进行激发试验。与对照组相比，接受30微克炔雌醇和左炔诺孕酮治疗的女性在GnRH/TRH第二次和第三次脉冲后的促黄体生成素（LH）反应减弱，而与对照组和接受30微克炔雌醇和左炔诺孕酮治疗的女性相比，接受50微克炔雌醇和左炔诺孕酮或炔诺酮治疗的女性在每次GnRH/TRH给药后的反应严重迟钝。接受30微克炔雌醇和左炔诺孕酮治疗的女性对GnRH/TRH的促卵泡生成素（FSH）反应与对照组相似，而与对照组和接受30微克以下炔雌醇和左炔诺孕酮治疗的女性相比，接受50微克炔雌醇和孕激素治疗的女性的反应有所降低。在接受30微克炔雌醇和左炔诺孕酮治疗的女性中，第二次和第三次脉冲后的催乳素（PRL）峰值高于第一次，且高于其他三组的值。
