Römmler A, Baumgarten S, Moltz L, Schwartz U, Hammerstein J
Contraception. 1985 Mar;31(3):295-303. doi: 10.1016/0010-7824(85)90098-8.
GnRH double stimulation (2 X 25 micrograms i.v. at a two-hour interval) was used to assess the dynamics of LH and FSH release in 25 healthy women on oral contraceptives, all containing 50 micrograms of ethinylestradiol (EE). The study included two sequential regimens (50 micrograms EE X 7 days, 50 micrograms EE + 0.125 mg desogestrel X 15 days; 50 micrograms EE X 7 days, 50 micrograms EE + 2.5 mg lynestrenol X 15 days) and three combined preparations (biphasic: 50 micrograms EE + 1 mg norethisterone acetate (NETA) X 11 days, 50 micrograms EE + 2 mg NETA X 10 days; monophasic: 50 micrograms EE + 2 mg cyproterone acetate X 21 days; 50 micrograms EE + 2.5 mg lynestrenol X 21 days). The tests were always performed on days 19 to 21 of the first treatment cycle and compared to results obtained in normally cycling controls and in women receiving 50 micrograms EE daily alone. It was found that the EE-induced augmentation of pituitary responsiveness to GnRH is diminished by the addition of progestins. LH and FSH reactions to stimulation were both affected. The degree of inhibition depended not only on the chemical structure and daily dose of the progestin component, but also on the duration of its administration per treatment cycle.
促性腺激素释放激素（GnRH）双重刺激（静脉注射2次，每次25微克，间隔2小时）用于评估25名服用口服避孕药的健康女性中促黄体生成素（LH）和促卵泡生成素（FSH）释放的动态变化，所有口服避孕药均含50微克炔雌醇（EE）。该研究包括两种序贯方案（50微克EE×7天，50微克EE + 0.125毫克去氧孕烯×15天；50微克EE×7天，50微克EE + 2.5毫克炔诺孕酮×15天）和三种复方制剂（双相型：50微克EE + 1毫克醋酸炔诺酮（NETA）×11天，50微克EE + 2毫克NETA×10天；单相型：50微克EE + 2毫克醋酸环丙孕酮×21天；50微克EE + 2.5毫克炔诺孕酮×21天）。测试均在第一个治疗周期的第19至21天进行，并与正常月经周期对照组以及单独每日服用50微克EE的女性所获结果进行比较。结果发现，添加孕激素会减弱EE诱导的垂体对GnRH反应性的增强。LH和FSH对刺激的反应均受到影响。抑制程度不仅取决于孕激素成分的化学结构和每日剂量，还取决于其在每个治疗周期中的给药持续时间。
