垂体中可能由白细胞介素1β诱导产生的白细胞介素6会刺激促性腺激素和催乳素的释放。
Interleukin 6 possibly induced by interleukin 1 beta in the pituitary gland stimulates the release of gonadotropins and prolactin.
作者信息
Yamaguchi M, Matsuzaki N, Hirota K, Miyake A, Tanizawa O
机构信息
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
出版信息
Acta Endocrinol (Copenh). 1990 Feb;122(2):201-5. doi: 10.1530/acta.0.1220201.
The abilities of recombinant human interleukin 1 (IL-1) and IL-6 to induce release of FSH, LH and PRL from rat pituitary cells in vitro were examined. IL-1 and IL-6 induced significant releases of FSH, LH and PRL within 3 h. The extents of release of these compounds induced by IL-1 and IL-6 were similar to those induced by GnRH and TRH. Rat anterior pituitary cells released IL-6 spontaneously, and its release was enhanced by IL-1 beta. This effect of IL-1 beta was inhibited significantly by a rabbit anti-IL-1 beta antiserum. These findings suggest that IL-1 induced the release of IL-6 from rat pituitary, and that the released IL-6 stimulated the secretions of FSH, LH and PRL.
研究了重组人白细胞介素1（IL-1）和IL-6在体外诱导大鼠垂体细胞释放促卵泡激素（FSH）、促黄体生成素（LH）和催乳素（PRL）的能力。IL-1和IL-6在3小时内诱导FSH、LH和PRL显著释放。IL-1和IL-6诱导这些化合物释放的程度与促性腺激素释放激素（GnRH）和促甲状腺激素释放激素（TRH）诱导的程度相似。大鼠垂体前叶细胞自发释放IL-6，IL-1β可增强其释放。兔抗IL-1β抗血清可显著抑制IL-1β的这种作用。这些发现表明，IL-1诱导大鼠垂体释放IL-6，释放的IL-6刺激FSH、LH和PRL的分泌。
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