高敏C反应蛋白：狼疮性肾炎患者左心室肥厚的独立危险因素。
High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with lupus nephritis.
作者信息
Shi Beili, Ni Zhaohui, Cai Hong, Zhang Minfang, Mou Shan, Wang Qin, Cao Liou, Yu Zanzhe, Yan Yucheng, Qian Jiaqi
机构信息
Renal Division, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, China.
出版信息
J Biomed Biotechnol. 2010;2010:373426. doi: 10.1155/2010/373426. Epub 2010 Nov 7.
OBJECTIVE
To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.
METHODS
287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.
RESULTS
The prevalence of LVH in this cohort was 21.25% (n = 61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22-30.95) versus 3.93 (1.48-9.48) mg/L, P < .01), and correlated with left ventricular mass index (LVMI) (r = 0.314, P = .001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (β = 0.338, P = .002) for LVH in patients with LN.
CONCLUSIONS
Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.
目的
确定狼疮性肾炎（LN）患者左心室肥厚（LVH）的患病率及其相关危险因素。
方法
招募了287例LN患者（年龄：38.54±13.31，女性262例）。测量了超声心动图和血清高敏C反应蛋白（hs-CRP）。通过单因素相关性分析和多因素回归分析评估它们之间的关系。
结果
该队列中LVH的患病率为21.25%（n = 61）。与无LVH的患者相比，LVH患者的血清hs-CRP水平显著升高（8.03（3.22 - 30.95）对3.93（1.48 - 9.48）mg/L，P <.01），并且与左心室质量指数（LVMI）相关（r = 0.314，P =.001）。多因素回归分析进一步证实，hs-CRP是LN患者LVH的独立危险因素（β = 0.338，P =.002）。
结论
我们的研究结果表明，血清hs-CRP水平与LVMI独立相关，并提示检测hs-CRP可能为研究LN患者的LVH提供重要的临床信息。
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