Siemińska Alicja
Klinika Alergologii Akademii Medycznej w Gdańsku.
Pneumonol Alergol Pol. 2010;78(6):432-8.
Numerous studies indicate genetical background of susceptibility to tobacco smoking. The current review presents new achievements and perspectives in searching for genes involved in tobacco smoking and dependence, which have been described in recent years as a result of the development of molecular techniques. It has been emphasized that tobacco smoking is a complex, polygenic behavior. Presence of multiple gene-gene and gene-environment interactions makes it difficult to find a strong genetic association. The causes of inconsistency in the results of candidate gene association studies, as well as the new perspectives in searching for genetic determinants of tobacco smoking, are also widely discussed. In particular, the focus is on the genome-wide association studies which allow the complex analysis of links between thousands of single nucleotide polymorphisms with smoking phenotypes.
大量研究表明吸烟易感性存在遗传背景。本综述介绍了近年来由于分子技术发展而发现的与吸烟及成瘾相关基因的新成果和新观点。强调了吸烟是一种复杂的多基因行为。多种基因-基因和基因-环境相互作用的存在使得难以找到强遗传关联。还广泛讨论了候选基因关联研究结果不一致的原因以及寻找吸烟遗传决定因素的新观点。特别关注全基因组关联研究，它能够对数千个单核苷酸多态性与吸烟表型之间的联系进行复杂分析。
