Buliakova N V, Azarova V S
Izv Akad Nauk Ser Biol. 2010 Sep-Oct(5):535-46.
The regeneration of gastrocnemius muscles of adult rats under implantation conditions in areas of muscle tissue damage in newborn rats has been studied. Alloplasty was performed using minced gastrocnemius and diaphragm muscles, which differs at birth in animals by degree of differentiation. The rat-recipient area of alloplasty was subjected to He-Ne laser radiation before operation, with the aim of reducing the immune response to allogenic muscle tissue. It has been shown that the number of regenerating myofibers produced in implanted gastrocnemius muscles is more than in alloplants from diaphragms. However, the formation of cartilage, bone, and adipose tissue foci were observed in the alloplastic region throughout the whole regeneration period. After implantation of minced diaphragm muscles, cartilage nodes were observed only in 7-day regenerates. At the end of observation, in the first instance, the area of muscle trauma in adult rat muscles was replaced by adipose tissue, even in the case of initial laser irradiation. During the implantation of diaphragm muscles, the area of trauma was filled with regenerating muscle tissue.
研究了成年大鼠腓肠肌在新生大鼠肌肉组织损伤区域植入条件下的再生情况。采用切碎的腓肠肌和膈肌进行同种异体移植，这两种肌肉在出生时动物的分化程度不同。同种异体移植的大鼠受体区域在手术前接受氦氖激光照射，目的是降低对同种异体肌肉组织的免疫反应。结果表明，植入的腓肠肌中产生的再生肌纤维数量比膈肌同种异体移植物中的多。然而，在整个再生期，在同种异体移植区域均观察到软骨、骨和脂肪组织灶的形成。植入切碎的膈肌后，仅在7天的再生组织中观察到软骨结节。观察结束时，首先，即使在最初进行激光照射的情况下，成年大鼠肌肉中的肌肉创伤区域也被脂肪组织取代。在植入膈肌时，创伤区域被再生的肌肉组织填充。
