Oğurlu M, Küçük M, Bilgin F, Sizlan A, Yanarateş O, Eksert S, Karaşahin E, Kurt E
Department of Anesthesiology and Reanimation, Adnan Menderes University, Aydin, USA.
Clin Exp Obstet Gynecol. 2010;37(3):209-12.
The study was conducted to determine whether bolus administrations of remifentanil-propofol could provide adequate analgesia and similar patient comfort with a faster recovery profile compared with bolus administrations of fentanyl-propofol during dilatation and sharp curettage.
The patients were randomized to a remifentanil group (n=36) or fentanyl group (n=36). The remifentanil group received an IV bolus dose of 1 pg kg(-1) remifentanil. The fentanyl group received an IV bolus dose of fentanyl 0.5 microg kg(-1). The Verbal Pain Scale (VPS), modified Aldrete scores, blood pressure, heart rate, peripheric oxygen saturation, recovery time from anesthesia and adverse events during or after surgery were evaluated.
The groups were found to be similar in duration of the surgical procedure, anesthesia time and hemodynamic variables and VPS scores. Patients in the remifentanil group recovered from anesthesia earlier. Modified Aldrete scores were higher in the remifentanil group at 5 and 10 min postoperatively. The frequency of perioperative adverse events did not differ significantly between the groups.
Bolus injections of remifentanil appear to be a safe and effective alternative to fentanyl, producing faster recovery in providing analgesia during dilatation and sharp curettage procedures.
本研究旨在确定在扩张刮宫术中，与注射芬太尼-丙泊酚相比，注射瑞芬太尼-丙泊酚是否能提供足够的镇痛效果、相似的患者舒适度以及更快的恢复情况。
将患者随机分为瑞芬太尼组（n = 36）或芬太尼组（n = 36）。瑞芬太尼组静脉注射1 μg·kg⁻¹瑞芬太尼。芬太尼组静脉注射0.5 μg·kg⁻¹芬太尼。评估言语疼痛量表（VPS）、改良Aldrete评分、血压、心率、外周血氧饱和度、麻醉恢复时间以及手术期间或术后的不良事件。
发现两组在手术时间、麻醉时间、血流动力学变量和VPS评分方面相似。瑞芬太尼组患者麻醉恢复更早。术后5分钟和10分钟时，瑞芬太尼组的改良Aldrete评分更高。两组围手术期不良事件的发生率无显著差异。
注射瑞芬太尼似乎是芬太尼的一种安全有效的替代方法，在扩张刮宫术期间提供镇痛时恢复更快。
