Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
Org Lett. 2010 Dec 17;12(24):5700-3. doi: 10.1021/ol102518v. Epub 2010 Nov 15.
A microwave-assisted, one-pot, iridium-catalyzed aromatic C-H borylation/rhodium-catalyzed 1,4-conjugate addition sequence provides a highly robust protocol suitable for high-throughput array synthesis. Selective formation of either β-aryl-substituted ketones or the corresponding alcohols can be achieved in good overall yields by simple variation of the reaction conditions.
微波辅助一锅法铱催化芳基 C-H 硼化/铑催化 1,4-共轭加成序列提供了一种高度稳健的协议，适用于高通量阵列合成。通过简单改变反应条件，可以以良好的总收率选择性地形成β-芳基取代的酮或相应的醇。
