Department of Food Science & Technology, Virginia Tech, Blacksburg, Virginia 24061, United States.
J Agric Food Chem. 2010 Dec 22;58(24):12950-6. doi: 10.1021/jf103275a. Epub 2010 Nov 15.
Sodium benzoate has been shown to produce benzene in combination with ascorbic acid. This has led to research for safe alternatives from plant essential oils and parabens that have shown some antimicrobial activity, but many of these compounds exhibit poor solubility in aqueous solutions. Cyclodextrins can increase the solubility of many compounds. This work aimed to investigate the solubility of 23 plant essential oils and 4 parabens in water and an apple juice medium. Four of these compounds were chosen for their low aqueous solubility to determine if complexing the compound with α- and β-cyclodextrin would increase solubility. Three of the complexes were dissolved in an acidified aqueous solution and then studied in glass and polyethylene terephthalate (PET) to determine if storage material would affect the stability. Solubility of the 27 compounds in distilled water ranged from 1.6 mg/L to 2460.6 mg/L and the solubility of 18 of the compounds decreased from 2.5 to 84.7% in apple juice medium (pH = 3.4, 12-13 °Brix). Complexation with cyclodextrin dramatically increased the solubility of the compounds, up to 10-fold. Packaging material had no effect on concentration of compounds present over 7 days. Cyclodextrins were able to increase solubility of these compounds to more suitable concentrations, and may lead to viable natural alternatives to sodium benzoate.
苯甲酸钠与抗坏血酸结合会生成苯。这促使人们从植物精油和对羟基苯甲酸酯中寻找安全的替代品，这些替代品已显示出一些抗菌活性，但许多此类化合物在水溶液中的溶解度较差。环糊精可以提高许多化合物的溶解度。这项工作旨在研究 23 种植物精油和 4 种对羟基苯甲酸酯在水和苹果汁介质中的溶解度。选择其中 4 种化合物，因为它们在水中的溶解度较低，以确定将化合物与 α-和 β-环糊精络合是否会增加溶解度。选择的 3 种复合物溶解在酸化的水溶液中，然后在玻璃和聚对苯二甲酸乙二醇酯 (PET) 中进行研究，以确定储存材料是否会影响稳定性。27 种化合物在蒸馏水中的溶解度范围为 1.6 至 2460.6 mg/L，在苹果汁介质（pH = 3.4，12-13°Brix）中，18 种化合物的溶解度从 2.5%至 84.7%下降。与环糊精络合可极大地提高化合物的溶解度，最高可达 10 倍。在 7 天内，包装材料对存在的化合物浓度没有影响。环糊精可以提高这些化合物的溶解度，使其达到更合适的浓度，并且可能成为苯甲酸钠的可行天然替代品。
