Melegh B, Kerner J, Szücs L, Porpáczy Z
Department of Pediatrics, University Medical School of Pécs, Hungary.
Acta Paediatr Hung. 1990;30(1):27-41.
A total of 29 preterm infants maintained on mixed enteral nutrition (50% pooled human milk, 50% formula daily) were studied over a 15 days period. 16 of them received L-carnitine supplemented formula during the first seven consecutive days (600 nmol/ml, as added supplement), 13 infants served as controls. In response to enhanced dietary intake, the plasma levels and urinary excretion rates of carnitines were increased by the 7th day of study. The plasma carnitines then returned to the initial values, whilst the urinary excretion remained elevated at the 14th day of study. The elevated daily urinary excretion of carnitines was accompanied by increased clearance and decreased relative reabsorption rates in the supplemented group. In the control group the plasma carnitine levels remained unchanged throughout the observations, while the daily excretion of free carnitine decreased by the end of the study. In the supplemented group statistically significant decrease was found in the daily excreted ammonia and urea with a decrease of plasma alanine and glutamine levels by the 7th day of study. The plasma levels of beta-hydroxybutyrate, glucose and creatinine remained unchanged in both groups.
共有29名接受混合肠内营养（每日50%人乳库奶、50%配方奶）的早产儿在15天内接受了研究。其中16名婴儿在连续的前七天接受添加左旋肉碱的配方奶（添加量为600纳摩尔/毫升），13名婴儿作为对照。随着饮食摄入量的增加，在研究的第7天，肉碱的血浆水平和尿排泄率升高。然后血浆肉碱恢复到初始值，而在研究的第14天尿排泄仍保持升高。在补充组中，肉碱每日尿排泄增加伴随着清除率增加和相对重吸收率降低。在对照组中，整个观察期间血浆肉碱水平保持不变，而在研究结束时游离肉碱的每日排泄减少。在补充组中，到研究的第7天，每日氨和尿素排泄量有统计学意义的下降，同时血浆丙氨酸和谷氨酰胺水平降低。两组中β-羟基丁酸、葡萄糖和肌酐的血浆水平均保持不变。
