固相萃取柱技术在高效液相色谱-荧光检测法检测麻痹性贝类毒素中的应用。
Solid core column technology applied to HPLC-FD of paralytic shellfish toxins.
机构信息
US FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, Spectroscopy and Mass Spectrometry Branch, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA.
出版信息
Toxicon. 2011 Jan;57(1):179-82. doi: 10.1016/j.toxicon.2010.11.004. Epub 2010 Nov 13.
Pre-column oxidation liquid chromatography with fluorescence detection is a chemical method for analyzing paralytic shellfish toxins. In order to improve the sample throughput and efficiency of AOAC Method 2005.06, solid core particle column technology was evaluated. We demonstrate that supplanting the original fully porous particle column with a solid core particle column reduces sample analysis time from 15 to 5 min per sample and improves resolution.
柱前氧化高效液相色谱-荧光检测法是分析麻痹性贝类毒素的一种化学方法。为了提高 AOAC 方法 2005.06 的样品通量和效率，我们对核壳型固定相技术进行了评估。结果表明，用核壳型固定相替代原有的完全多孔颗粒柱，可将每个样品的分析时间从 15 分钟缩短至 5 分钟，并提高分辨率。
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