Klingensmith William C, Rhea Katherine L, Wainwright Elizabeth A, Hopper Orlin Woodie
Department of Radiology, Porter Hospital, Denver, Colorado, USA.
J Nucl Med Technol. 2010 Dec;38(4):186-90. doi: 10.2967/jnmt.110.077065. Epub 2010 Nov 15.
This study evaluated the reference range and reproducibility of the gastric emptying study with oatmeal as a function of age and sex.
Twenty-four healthy subjects, 12 men and 12 women, categorized into 3 age groups, 20-40, 40-60, and 60-80 y, were studied twice, 1 d apart, with instant oatmeal labeled with (99m)Tc-sulfur colloid. Imaging was performed in the upright position using the left anterior oblique (LAO), right posterior oblique (RPO), anterior, and posterior projections. One-minute digital images acquired every 15 min for 60 min were used to calculate a simple half-time of emptying.
A strong correlation was found among half-times of gastric emptying calculated from the anterior projection, LAO projection, anterior-posterior geometric mean, and LAO-RPO geometric mean (P < 0.01). A significant inverse correlation was found between increasing age and decreasing half-time of emptying in men and women (P < 0.05). A reference range of 10-60 min is suggested for 20- to 40-y-old patients, 10-40 min for 40- to 60-y-olds, and 10-30 min for 60- to 80-y-olds. Half-times of emptying tended to be longer for women than for men (not statistically significant). There was a large variation between the first and second studies, with a trend toward decreasing variation with increasing age in both men and women. In repeated studies, a reference range of variation of up to 30 min is suggested for 20- to 40-y-old patients, up to 20 min for 40- to 60-y-olds, and up to 15 min for 60- to 80-y-olds.
The reference range for half-time of gastric emptying with instant oatmeal decreases with increasing age in both men and women. Test-retest variation is relatively large and tends to decrease with increasing age in both men and women. Data from either the LAO projection or the anterior-posterior geometric mean are acceptable for calculating the half-time of gastric emptying.
本研究评估了以燕麦片为食物的胃排空研究的参考范围及可重复性，并分析其与年龄和性别的关系。
24名健康受试者，12名男性和12名女性，分为3个年龄组，20 - 40岁、40 - 60岁和60 - 80岁，相隔1天进行两次研究，食用标记有（99m）锝 - 硫胶体的即食燕麦片。采用左前斜位（LAO）、右后斜位（RPO）、前后位进行立位成像。每15分钟采集1分钟数字图像，共60分钟，用于计算简单排空半衰期。
在前位、LAO位、前后位几何均值和LAO - RPO位几何均值计算的胃排空半衰期之间发现强相关性（P < 0.01）。男性和女性年龄增加与排空半衰期缩短之间存在显著负相关（P < 0.05）。建议20至40岁患者的参考范围为10 - 60分钟，40至60岁为10 - 40分钟，60至80岁为10 - 30分钟。女性的排空半衰期往往比男性长（无统计学意义）。第一次和第二次研究之间存在较大差异，且男性和女性均有随年龄增长差异减小的趋势。在重复研究中，建议20至40岁患者的变异参考范围高达30分钟，40至60岁为20分钟，60至80岁为15分钟。
男性和女性以即食燕麦片为食物的胃排空半衰期参考范围均随年龄增长而降低。重测变异相对较大，且男性和女性均有随年龄增长而减小的趋势。LAO位或前后位几何均值的数据均可用于计算胃排空半衰期。
