Datz F L, Christian P E, Moore J
J Nucl Med. 1987 Jul;28(7):1204-7.
This study was undertaken to determine if men and women have similar rates of gastric emptying. Fifteen normal weight male subjects aged 20-53 yr (mean 30 yr) and 15 normal weight female subjects aged 20-45 yr (mean 32 yr) were studied. Each subject ingested an identical 300-g meal consisting of 150 g of beef stew and 150 g of orange juice. Technetium-99m-(99mTc) labeled liver pate was used as the radioactive marker for the solid phase; indium-111 DTPA [( 111In]DTPA) was the liquid marker. A scintillation camera and computer was used to measure the rate of emptying of the solid and liquid phases. Correction for radionuclide depth, decay, and crosstalk was performed. The half-emptying time for men was: solids 59.8 +/- 3.7 min, liquids 30.3 +/- 2.3 min, and for women was: solids 92.4 +/- 7.5 min, liquids 53.8 +/- 4.9 min. These differences were statistically significant (solids, p = 0.00097; liquids, p = 0.00038). We conclude that women empty both solids and liquids from their stomachs more slowly than men. Possible mechanisms for the difference in gastric emptying rates between men and women are discussed.
本研究旨在确定男性和女性的胃排空速率是否相似。对15名年龄在20 - 53岁（平均30岁）的正常体重男性受试者和15名年龄在20 - 45岁（平均32岁）的正常体重女性受试者进行了研究。每位受试者摄入一份相同的300克餐食，其中包括150克炖牛肉和150克橙汁。用锝 - 99m（99mTc）标记的肝泥作为固相的放射性标记物；铟 - 111二乙三胺五乙酸（[111In]DTPA）作为液相标记物。使用闪烁相机和计算机来测量固相和液相的排空速率。对放射性核素深度、衰变和串扰进行了校正。男性的半排空时间为：固相59.8±3.7分钟，液相30.3±2.3分钟；女性的半排空时间为：固相92.4±7.5分钟，液相53.8±4.9分钟。这些差异具有统计学意义（固相，p = 0.00097；液相，p = 0.00038）。我们得出结论，女性胃内固体和液体的排空速度均比男性慢。文中讨论了男性和女性胃排空速率差异的可能机制。
