Department of Nuclear Cardiology and Cardiac Imaging, Instituto Nacional de Cardiología Ignacio Chávez, México City, México.
J Nucl Med. 2010 Dec;51(12):1927-31. doi: 10.2967/jnumed.110.078212. Epub 2010 Nov 15.
Systemic lupus erythematosus (SLE) affects multiple organs and systems, severely involving the cardiovascular system. The aim of this study was to evaluate the presence of endothelial dysfunction with (13)N-ammonia PET in asymptomatic SLE patients.
We enrolled 16 women with SLE and 16 healthy women. Myocardial blood flow (MBF) was quantified in a 64-slice PET/CT scanner at rest, during a cold pressor test (CPT), and during stress. Endothelium-dependent vasodilation index, %ΔMBF, and myocardial flow reserve (MFR) were calculated.
There were 16 women in the SLE group (mean age ± SD, 31.4 ± 8.3 y) and 16 women in the healthy control group (31.5 ± 11.1 y). Mean endothelium-dependent vasodilatation index and %ΔMBF were significantly lower in SLE patients (1.18 ± 0.55 vs. 1.63 ± 0.65, P = 0.04, and 18 ± 55 vs. 63 ± 65, P = 0.04, respectively). MFR was also lower in the SLE group (2.41 ± 0.59 vs. 2.73 ± 0.77, P = 0.20).
SLE patients who are free of active disease present abnormal coronary flow and endothelial dysfunction. It is necessary to develop and intensify treatment strategies directed to CAD in SLE patients.
本研究旨在通过（13）N-氨 PET 评估无症状 SLE 患者是否存在内皮功能障碍。
我们纳入了 16 名女性 SLE 患者和 16 名健康女性。在 64 层 PET/CT 扫描仪上，在静息、冷加压试验（CPT）和应激期间定量心肌血流（MBF）。计算内皮依赖性血管扩张指数、%ΔMBF 和心肌血流储备（MFR）。
SLE 组有 16 名女性（平均年龄±标准差，31.4±8.3 岁），健康对照组有 16 名女性（31.5±11.1 岁）。SLE 患者的内皮依赖性血管舒张指数和%ΔMBF 明显降低（1.18±0.55 比 1.63±0.65，P=0.04；18±55 比 63±65，P=0.04）。MFR 在 SLE 组也较低（2.41±0.59 比 2.73±0.77，P=0.20）。
无活动性疾病的 SLE 患者存在异常的冠状动脉血流和内皮功能障碍。有必要为 SLE 患者制定和加强针对 CAD 的治疗策略。
