Alexanderson Erick, Rodriguez-Valero Mónica, Martinez Alfonso, Calleja Rodrigo, Lamothe Pedro A, Sierra Carlos, Garcia-Rojas Leonardo, Talayero Jose Antonio, Cruz Patricio, Meave Aloha, Alexanderson Graciela
Universidad Nacional Autonoma de Mexico, Mexico City.
Mol Imaging Biol. 2009 Jan-Feb;11(1):1-5. doi: 10.1007/s11307-008-0173-0. Epub 2008 Sep 3.
To demonstrate the presence of endothelial dysfunction (ED) in asymptomatic patients with type 2 diabetes mellitus (DM) by using (13)N-ammonia-positron emission tomography (PET). PET can identify ED by quantifying myocardial blood flow (MBF) during rest, cold pressor test (CPT), and pharmacologic stress. The endothelial-dependent vasodilation index (EDVI), myocardial flow reserve (MFR), and the percentage of the change between rest and CPT (%DeltaMBF) are markers of endothelial function.
Thirty-nine subjects were studied (19 women and 20 men); 22 recently diagnosed type 2 diabetic patients and 17 healthy controls (HC). A three-phase (13)N-ammonia-PET was performed.
Mean EDVI was 1.208 +/- 0.34 vs. 1.55 +/- 0.37 (diabetic vs. HC group, respectively) (p = 0.002), MFR was 2.803 +/- 1.39 vs. 3.27 +/- 0.72 (p = NS), and the %DeltaMBF was 20 +/- 34% vs. 55 +/- 37% (p = 0.002). Rest MBF and CPT MBF were normalized to the rate pressure product (RPP). EDVI' and %DeltaMBF' were calculated using the corrected values for the RPP. Mean EDVI' was (0.864 +/- 0.250 vs. 1.110 +/- 0.238, p = 0.004) and mean %DeltaMBF' was (-8.2 +/- 14.7% vs. 4.5 +/- 12.1%, p = 0.005).
Asymptomatic, recently diagnosed type 2 diabetes patients present ED that can be quantified by (13)N-ammonia-PET.
通过使用¹³N - 氨正电子发射断层扫描（PET）来证明2型糖尿病（DM）无症状患者存在内皮功能障碍（ED）。PET可通过在静息、冷加压试验（CPT）和药物负荷试验期间量化心肌血流量（MBF）来识别ED。内皮依赖性血管舒张指数（EDVI）、心肌血流储备（MFR）以及静息和CPT之间的变化百分比（%ΔMBF）是内皮功能的标志物。
对39名受试者进行了研究（19名女性和20名男性）；22名新诊断的2型糖尿病患者和17名健康对照者（HC）。进行了三相¹³N - 氨PET检查。
平均EDVI为1.208±0.34，而对照组为1.55±0.37（分别为糖尿病组与HC组）（p = 0.002），MFR为2.803±1.39，而对照组为3.27±0.72（p =无统计学意义），%ΔMBF为20±34%，而对照组为55±37%（p = 0.002）。静息MBF和CPT MBF根据心率血压乘积（RPP）进行了标准化。使用RPP的校正值计算EDVI'和%ΔMBF'。平均EDVI'为（0.864±0.250对1.110±0.238，p = 0.004），平均%ΔMBF'为（-8.2±14.7%对4.5±12.1%，p = 0.005）。
新诊断的无症状2型糖尿病患者存在可通过¹³N - 氨PET量化的ED。
