Department of Dermatology, Venereology and Leprology, Pt. B. D. Sharma University of Health Sciences, Rohtak, Haryana, India.
Indian J Dermatol Venereol Leprol. 2010 Nov-Dec;76(6):666-70. doi: 10.4103/0378-6323.72464.
Very few studies using the combination of topical 8-methoxypsoralen (8-MOP) and narrow-band ultraviolet B (NBUVB) have been performed, especially in Indian patients. A combination of oral psoralen with NBUVB has been shown to have a superior efficacy as compared with NBUVB alone in psoriasis.
Comparison of the efficacy of topical psoralen NBUVB (combination) versus NBUVB alone in psoriasis.
Thirty patients with plaque psoriasis were taken up for the study and NBUVB phototherapy was given twice weekly. The target lesions on one side were treated with 0.1% topical 8-MOP 15 min before the irradiation. The treatment period was 12 weeks or 24 exposures.
The number of treatment sessions and cumulative NBUVB doses were lower in the combination therapy as compared with NBUVB monotherapy, although the differences were not statistically significant.
To conclude, topical 8-MOP enhances the therapeutic effects of NBUVB therapy without increasing the incidence of adverse effects.
使用局部 8-甲氧基补骨脂素（8-MOP）和窄谱中波紫外线（NBUVB）联合治疗的研究很少，特别是在印度患者中。与单独使用 NBUVB 相比，口服补骨脂素联合 NBUVB 治疗银屑病具有更好的疗效。
比较局部补骨脂素 NBUVB（联合治疗）与单独使用 NBUVB 治疗银屑病的疗效。
选择 30 例斑块状银屑病患者进行研究，每周接受两次 NBUVB 光疗。在照射前 15 分钟，一侧的靶病变部位用 0.1%的局部 8-MOP 治疗。治疗期为 12 周或 24 次照射。
与 NBUVB 单药治疗相比，联合治疗的治疗次数和累积 NBUVB 剂量较低，但差异无统计学意义。
总之，局部 8-MOP 增强了 NBUVB 治疗的疗效，而不增加不良反应的发生率。
