Department of Dermatology, T.N. Medical College and B.Y.L. Nair Ch. Hospital, Mumbai Central, Mumbai, India.
Indian J Dermatol Venereol Leprol. 2010 Nov-Dec;76(6):695-8. doi: 10.4103/0378-6323.72474.
Subcutaneous phaeohyphomycosis is an infection of the skin and subcutaneous tissue, caused by dematiaceous fungi. An adult male presented with a history of multiple reddish nodules over the face and hands. Histopathological examination of the skin biopsies showed a dense granulomatous infiltrate of macrophages, containing intracytoplasmic basophilic bodies throughout the dermis. Gomori methenamine-silver stained sections revealed yeast cells within macrophages. Multiple cultures on Sabouraud's dextrose agar grew Cladophialophora boppii. The patient was treated with oral itraconazole for a year and the response monitored with dermal ultrasound. This is the first case report of subcutaneous phaeohyphomycosis caused by Cl. boppii in India.
皮下暗色丝孢霉病是一种皮肤和皮下组织的感染，由暗色真菌引起。一名成年男性面部和手部有多处红色结节的病史。皮肤活检的组织病理学检查显示，真皮内有密集的巨噬细胞肉芽肿浸润，胞质内含有嗜碱性小体。Gomori 六氨银染色切片显示巨噬细胞内有酵母细胞。在萨布罗琼脂上进行的多次培养长出了拟青霉。患者接受了一年的口服伊曲康唑治疗，并通过皮肤超声监测反应。这是印度首例由拟青霉引起的皮下暗色丝孢霉病的病例报告。
